A Retrospective Observational Cohort Study on the Success of Non-Invasive Respiratory Support (NIRS) Treatments and the Factors Affecting the Success of NIRS in Coronavirus Disease-Related Acute Respiratory Distress Syndrome (ARDS)

Purpose: Non-invasive respiratory therapy is widely used as an important part of treatment in severe cases. We aimed to determine the factors affecting the success of NIRS in Covid-19-related acute respiratory distress syndrome cases. Materials and Methods: 209 patients with severe Covid-19 infection who were hospitalised in the intensive care unit of our hospital between August 2020 and May 2021 were included in the study. The patients’ demographic information, Acute Physiology and Chronic Health Evaluation-II (APACHE-II) and Sequential Organ Failure Assessment (SOFA) scores, heart rates, acidosis, consciousness, oxygenation, respiratory rates and laboratory results were recorded and analysed. Results: Advanced age, HT, chronic obstructive pulmonary disease, high APACHE and SOFA scores, low albumin levels, high LDH levels, and low PaO2/FiO2 were found to be the factors that reduced NIRS success. Additionally, we determined that low PaO2/FiO2 and SatO2 and blood PH increased early-stage failure. Conclusion: Our findings suggest that NIRS can be an effective treatment method for Covid-19 patients and that NIRS applied in the early stages of the disease can reduce the risk of intubation and mortality.