Biocompatibility and tissue integration of autologous fat grafts and synthetic implants following submucosal implantation into the urinary bladder

The combination of platelet-rich plasma (PRP) with an autologous fat graft, as well as the use of the synthetic material polyacrylate and polyvinyl alcohol copolymer, appear to be the most promising approaches for achieving a stable and biocompatible volume-forming effect in the correction of lower urinary tract pathologies. At the same time, despite the confirmed high biocompatibility of the investigated substrates in the short term, questions regarding their long-term safety remain unresolved, including the risk of fibrotic changes and potential functional impairments of the urinary bladder. These aspects warrant further investigation and clinical validation.