Different Role of CSF MMPs in Amyloid Pathology and Cerebrovascular Pathology

This study suggested the involvement of MMPs in the cerebrovascular damage and the protective role of MMP2 in amyloid pathology, which highlight that the clinical application of MMP inhibitors should consider the protective effect of MMP2 on amyloid pathology.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_098315
Primary Topic
Protease and Inhibitor Mechanisms
Type
article
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article

Different Role of CSF MMPs in Amyloid Pathology and Cerebrovascular Pathology

Fei Gao, Yaxi Zhan, Yong Shen
Alzheimer s & Dementia
Protease and Inhibitor Mechanisms
article

Different Role of CSF MMPs in Amyloid Pathology and Cerebrovascular Pathology

Fei Gao, Yaxi Zhan, Yong Shen
article en

Abstract

This study suggested the involvement of MMPs in the cerebrovascular damage and the protective role of MMP2 in amyloid pathology, which highlight that the clinical application of MMP inhibitors should consider the protective effect of MMP2 on amyloid pathology.

Alzheimer s & DementiaVol. 21(S2)
University of Science and Technology of China (CN)
Openalex Percentile: Top 33%
Protease and Inhibitor Mechanisms
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Different Role of CSF MMPs in Amyloid Pathology and Cerebrovascular Pathology — Fei Gao, Yaxi Zhan, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS