Metformin Increased Histone Deacetylases 1, 3, and 8 Expressions as Epigenetic Regulators in Type 2 Diabetic Patients
The current findings suggest that <i>HDAC1</i>, <i>3</i>, and <i>8</i> genes expression are affected by metformin, and obesity has a substantial ability to increase the risk of diabetes. However, changes in HDAC expression may represent potential biomarkers and therapeutic targets for future clinical studies in diabetes, particularly in exploring combination therapies involving histone deacetylase inhibitors and metformin.
Authors
- Sohrab Boozarpour (ORCID: https://orcid.org/0000-0003-0873-7499)
- Mina Lashkarboloki (ORCID: https://orcid.org/0000-0002-9074-7698)
- Masoud Fahimi
- Madjid Momeni Moghaddam
- Mohsen Ghalandar
- Amin Izadi
- Azam Zarourati
Institutions
- Tarbiat Modares University (IR)
- Hakim Sabzevari University (IR)
- Gonbad Kavous University (IR)
Publication Details
- Journal
- Reports of Biochemistry and Molecular Biology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.61882/rbmb.14.1.85
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gonbad Kavous University