Interlaboratory comparison of amyloid‐beta [AB1‐42], [AB1‐40] and its ratio derived from CSF at two reference laboratories using the lumipulse platform

The CSF Aβ1-42/Aβ1-40 ratio results from two independent laboratories are statistically identical. A slope of 0.964, with 95% confidence interval including 1.00, and an intercept of 0.0011, with 95% confidence interval including 0.0, indicate a statistically significant positive correlation between the ratio values obtained in each laboratory. Additionally, Positive/abnormal, Likely Positive and Negative CSF Aβ1-42/Aβ1-40 ratio interpretations are identical between each laboratory.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103706
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
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article

Interlaboratory comparison of amyloid‐beta [AB1‐42], [AB1‐40] and its ratio derived from CSF at two reference laboratories using the lumipulse platform

F. Simone, Fred Kim, Jai Jun Choung, Saeed A. Jortani et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Interlaboratory comparison of amyloid‐beta [AB1‐42], [AB1‐40] and its ratio derived from CSF at two reference laboratories using the lumipulse platform

F. Simone, Fred Kim, Jai Jun Choung, Saeed A. Jortani, Shaofeng Zhang, Natalya Benina, Rachel R. Radwan, James Arthur Rock, Tao Han, Anna McGuffin
article en

Abstract

The CSF Aβ1-42/Aβ1-40 ratio results from two independent laboratories are statistically identical. A slope of 0.964, with 95% confidence interval including 1.00, and an intercept of 0.0011, with 95% confidence interval including 0.0, indicate a statistically significant positive correlation between the ratio values obtained in each laboratory. Additionally, Positive/abnormal, Likely Positive and Negative CSF Aβ1-42/Aβ1-40 ratio interpretations are identical between each laboratory.

Alzheimer s & DementiaVol. 21(S2)
Autism Research Institute (US), University of Louisville (US), Kentuckiana Pulmonary Associates (US), Adone (South Korea) (KR), Yangpu Hospital of Tongji University (CN)
Openalex Percentile: Top 34%
Dementia and Cognitive Impairment Research
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