Identifying brain regions to characterize AD using PET tracer uptake: A Bayesian approach

In this work, regional standardized uptake value ratios (SUVR) from PIB-PET scans are analyzed to examine key brain regions linked to AD diagnosis. Tracer uptake in 13 of these regions and global amyloid deposition are identified to be highly linked to disease status, that could serve as markers and inform about the likelihood of AD in patients. Future studies could explore tracer uptake in these regions in larger cohorts to confirm their utility in AD diagnosis and treatment. Data was provided by OASIS-3 (LaMontagne et al., 2019) and all analyses were carried out on AD Workbench (2020), Alzheimers Disease Data Initiative (https://www.alzheimersdata.org/). This work was funded by the AD Data Initiative.