Assessment of the influence of Apolipoprotein E on the deposition of Arctic Aβ and seeded deposits in knock‐in and transgenic mouse models
We conclude that apoE variants broadly influence the rate of amyloid deposition, but do not modify the morphology of the resulting deposits or colocalization with Aβ. Notably, when seeding with AD patient brain lysate, there was no significant difference in Aβ burden between APPsi mice expressing APOE E3 and E4. Our study adds insights into the role of apoE isoforms in determining Aβ-related phenotype.
Authors
- Guilian Xu (ORCID: https://orcid.org/0000-0001-9630-1534)
- Susan Fromholt
- Quan Vo (ORCID: https://orcid.org/0000-0001-5168-2628)
- Karen N. McFarland (ORCID: https://orcid.org/0000-0002-9952-8678)
- David Borchelt (ORCID: https://orcid.org/0000-0002-0813-6979)
- Conner Angelle
- Andrea Iturbe
- Paramita Chakrabarty (ORCID: https://orcid.org/0000-0002-6226-3776)
- Patricia Sacilotto
- Stefan Prokop
Institutions
- WinnMed (US)
- University of Florida (US)
- Mayo Clinic in Florida (US)
- Florida College (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107455
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00