AstroID resource: a scalable, relational database structure for longitudinal biomarker discovery
This effort provides a database model for investigators conducting research on large volumes of biospecimens with clinical annotation. We have now deployed this structure in our laboratories and have over 1B cells spatially mapped, each effectively tagged with the clinical information from longitudinal patient experiences. While the description uses the example of cancer biomarkers, this data structure could be used to characterize longitudinal biospecimens from any disease process. In the near future, automatic synchronization between the electronic medical record and one or more AstroID databases is anticipated.
Authors
- Evan J. Lipson (ORCID: https://orcid.org/0000-0003-2976-0911)
- Andrew Jorquera
- Sigfredo Soto-Diaz (ORCID: https://orcid.org/0009-0007-5516-6330)
- Alexander S. Szalay (ORCID: https://orcid.org/0000-0002-4108-3282)
- Joel Sunshine (ORCID: https://orcid.org/0000-0001-9987-6712)
- Ludmila Danilova (ORCID: https://orcid.org/0000-0003-2813-3094)
- Janis M. Taube (ORCID: https://orcid.org/0000-0002-8273-4395)
- L. A. Cope
- Govind Warrier (ORCID: https://orcid.org/0000-0002-6625-448X)
- Scott Carey (ORCID: https://orcid.org/0000-0003-3638-9188)
- Aasheen Qadri (ORCID: https://orcid.org/0009-0001-9169-5754)
- Julie S. Deutsch (ORCID: https://orcid.org/0000-0002-8040-5205)
- Tricia R. Cottrell (ORCID: https://orcid.org/0000-0003-2952-1830)
- L. Engle
- Benjamin Green (ORCID: https://orcid.org/0000-0002-2461-1274)
- Elizabeth Will
- Qingfeng C Zhu
- Robert A Anders
- Daphne Wang
Institutions
- Johns Hopkins University (US)
- Queen's University (CA)
- Johns Hopkins Medicine (US)
- Foundation Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-012235
- Primary Topic
- Cell Image Analysis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Melanoma Research Alliance
- Johns Hopkins University
- Regeneron Pharmaceuticals
- Mark Foundation For Cancer Research
- Moderna
- Genentech
- National Cancer Institute