Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum

Our data suggest that, in CU individuals, soluble Ab and p-tau exert opposite effects in the DAN information flow. Moreover, our interaction models suggest that a lower integration between DMN and the rest of the brain, as well as a lower centrality of DMN regions might be beneficial to preserve cognitive performance in the presence of AD. This study highlights the role of network topology in early AD and its potential to support cognitive resilience, providing potential targets for intervention.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_099727
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum

José María Gónzalez‐de‐Echávarri, Aldana Lizarraga, Raffaele Cacciaglia, Jordi Huguet et al.
Alzheimer s & Dementia
Functional Brain Connectivity Studies
article

Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum

José María Gónzalez‐de‐Echávarri, Aldana Lizarraga, Raffaele Cacciaglia, Jordi Huguet, Gemma Salvadó, Gwendlyn Kollmorgen, Kaj Blennow, Michalis Kassinopoulos, Clara Quijano‐Rubio, Gonzalo Sánchez‐Benavides, Oriol Grau‐Rivera, Marta Milà‐Alomà, Juan Domingo Gispert, Marc Suárez‐Calvet, Henrik Zetterberg
article en

Abstract

Our data suggest that, in CU individuals, soluble Ab and p-tau exert opposite effects in the DAN information flow. Moreover, our interaction models suggest that a lower integration between DMN and the rest of the brain, as well as a lower centrality of DMN regions might be beneficial to preserve cognitive performance in the presence of AD. This study highlights the role of network topology in early AD and its potential to support cognitive resilience, providing potential targets for intervention.

Alzheimer s & DementiaVol. 21(S2)
Roche (Switzerland) (CH), University of Wisconsin–Madison (US), Universitat Pompeu Fabra (ES), Lund University (SE), Hong Kong Science and Technology Parks Corporation (HK), Sahlgrenska University Hospital (SE), Roche Pharma AG (Germany) (DE), Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES), Pasqual Maragall Foundation (ES), Barcelonaβeta Brain Research Center (ES), Hospital Del Mar (ES), MRC Prion Unit (GB), Wisconsin Division of Public Health (US), Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES), Northern California Institute for Research and Education (US), University College London (GB), University of Gothenburg (SE)
Openalex Percentile: Top 33%
Functional Brain Connectivity Studies
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