Association between growth differentiation factor‐15 (GDF‐15) with neurofilament light chain (NfL) and lower cognitive function with mediation from pulse pressure
GDF-15 was associated with higher NfL and lower cognitive function in older individuals, with mediation from PP. GDF-15 may play a potential role in cognitive impairment. These results may pave the way for future longitudinal studies and interventions targeting GDF-15 and even PP in an effort to screen and prevent cognitive impairment.
Authors
- Serena Low (ORCID: https://orcid.org/0000-0003-1716-0871)
- Kiat Sern Goh
Institutions
- Changi General Hospital (SG)
- Khoo Teck Puat Hospital (SG)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098746
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00