Tasks discriminating cognitive impairment levels: Item Response Theory applied to the Alzheimer's Disease Assessment Scale Cognitive Subscale
Seven items separated placebo from donepezil in five pivotal clinical trials of donepezil compared with placebo for Alzheimer's disease. The current study contributes to knowledge on Alzheimer's disease by identifying tasks that discriminate cognitive impairment levels, with potential use for treatment monitoring in moderate-stage Alzheimer's disease.
Authors
- Andrea Cipriani (ORCID: https://orcid.org/0000-0001-5179-8321)
- Kazufumi Yoshida (ORCID: https://orcid.org/0000-0003-4475-8043)
- Anat Rotstein (ORCID: https://orcid.org/0000-0001-8634-9577)
- Yair Goldberg (ORCID: https://orcid.org/0000-0002-4544-0910)
- Myrto Samara (ORCID: https://orcid.org/0000-0002-6943-5091)
- Takeshi Iwatsubo
- Toshiaki A. Furawaka
- S. Leucht
- Stephen Z Levine
Institutions
- Technion – Israel Institute of Technology (IL)
- Kyoto University (JP)
- University of Oxford (GB)
- National Center of Neurology and Psychiatry (JP)
- University of Tokyo Hospital (JP)
- Technical University of Munich (DE)
- The University of Tokyo (JP)
- University of Haifa (IL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_096753
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00