Molecular signatures of LATE‐NC: insights from transcriptomic analyses
Our findings highlight distinct molecular signatures of LATE-NC in the amygdala, including upregulation of microtubule-related pathways and downregulation of neuronal/synaptic genes. Interestingly, this LATE-NC signature was much weaker in the neocortex, underscoring the critical importance of brain-region-specific multi-omic studies in neurodegeneration. Our results provide one of the first large-scale molecular atlas of LATE-NC from the limbic region, providing foundations for disease models, biomarker discovery, and therapeutic approaches.
Authors
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- David H. Adamowicz (ORCID: https://orcid.org/0000-0002-4769-9096)
- Vladislav Petyuk (ORCID: https://orcid.org/0000-0003-4076-151X)
- Y. Wang
- Jishu Xu (ORCID: https://orcid.org/0000-0002-3679-6579)
- Ling Teng
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Jijing Wang
- Hyun‐Sik Yang
- Lei Liu
- Zheng Yin
- Sashini L De Tissera
- Philip L. De Jager
- David A. A. Bennett
- Julie A Schneider
- Nicola Kearns
Institutions
- Broad Institute (US)
- Rush University Medical Center (US)
- Harvard University (US)
- Pacific Northwest National Laboratory (US)
- Columbia University Irving Medical Center (US)
- Mass General Brigham (US)
- Rush University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098456
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00