Host‐dependent variability in amyloid‐beta propagation and deposition
This study shows that different hosts react differently to the same Aβ sources, thus suggesting the formation of different Aβ strains, which in turn may determine diverse pathological features. Investigating the pathological significance of Aβ strains is also relevant in light of recent reports of potential inter-individual transmission of Aβ. Finally, our investigations may pave the way to personalized diagnostic approaches and treatments.
Authors
- Salvatore Saieva (ORCID: https://orcid.org/0000-0001-9586-6920)
- Nazaret Gamez (ORCID: https://orcid.org/0000-0001-6847-7735)
- Rodrigo A. V. Morales (ORCID: https://orcid.org/0000-0002-7973-356X)
- Yumeng Huang
- Claudia Duran‐Aniotz
- Catalina Valdes
- Javiera Bravo‐Alegria
Institutions
- Houston Methodist (US)
- Adolfo Ibáñez University (CL)
- The University of Texas Medical Branch at Galveston (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105111
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.00