Analysis of full-field electroretinography parameters and potential for monitoring functional retinal deterioration in unilateral retinal vasculitis

To elucidate changes of full-field electroretinography (ffERG) tests in active unilateral retinal vasculitis, using the unaffected fellow eye as an internal control. Despite no significant differences in best corrected visual acuity (p=0.100) or central subfield macular thickness (p=0.084) at baseline, ffERG showed significant reductions in five of eight amplitudes (i.e. DA10 a-wave, p<0.001) and delays in six of eight implicit times (i.e. light-adapted Flicker, p=0.002). At follow-up ffERG, following management for retinal vasculitis, the implicit times normalised, coinciding with inflammation reduction. However, the amplitude reductions persisted. In ffERG, the implicit time might be a sensitive biomarker for retinal vasculitis activity and the amplitude might be one for permanent functional loss.

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Publication Details

Journal
British Journal of Ophthalmology
Published
2025-12-25
DOI
https://doi.org/10.1136/bjo-2025-328457
Primary Topic
Ocular Diseases and Behçet’s Syndrome
Type
article
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article

Analysis of full-field electroretinography parameters and potential for monitoring functional retinal deterioration in unilateral retinal vasculitis

Irmak Karaca, Zheng Xian Thng, Amir Akhavanrezayat, Christopher Or et al.
British Journal of Ophthalmology
Ocular Diseases and Behçet’s Syndrome
article

Analysis of full-field electroretinography parameters and potential for monitoring functional retinal deterioration in unilateral retinal vasculitis

Irmak Karaca, Zheng Xian Thng, Amir Akhavanrezayat, Christopher Or, Günay Uludağ, Albert John Bromeo, Azadeh Mobasserian, Anadi Khatri, Çigdem Yaşar, Prapatsorn Ongpalakorn, Jia-Horung Hung, Ankur Gupta, Anh Ngọc Tram Tran, Xun Lyu, Woong-Sun Yoo, Hashem Ghoraba, Hassan Khojasteh, Sungwho Park, Yong Un Shin, Diana V Do, Quan Dong Nguyen
article en

Abstract

To elucidate changes of full-field electroretinography (ffERG) tests in active unilateral retinal vasculitis, using the unaffected fellow eye as an internal control. Despite no significant differences in best corrected visual acuity (p=0.100) or central subfield macular thickness (p=0.084) at baseline, ffERG showed significant reductions in five of eight amplitudes (i.e. DA10 a-wave, p<0.001) and delays in six of eight implicit times (i.e. light-adapted Flicker, p=0.002). At follow-up ffERG, following management for retinal vasculitis, the implicit times normalised, coinciding with inflammation reduction. However, the amplitude reductions persisted. In ffERG, the implicit time might be a sensitive biomarker for retinal vasculitis activity and the amplitude might be one for permanent functional loss.

British Journal of Ophthalmology
University of Toronto (CA), Bir Hospital (NP), Biratnagar Eye Hospital (NP), Tan Tock Seng Hospital (SG), California Retina Consultants (US), Gyeongsang National University Hospital (KR), Pusan National University Hospital (KR), Nopparat Rajathanee Hospital (TH), Kensington Health (CA), Asian Eye Institute (PH), Eriez (United States) (US), Hanyang University (KR), Smith-Kettlewell Eye Research Institute (US), Columbia University (US), Stanford University (US)
Openalex Percentile: Top 29%
Ocular Diseases and Behçet’s Syndrome
DOISourceOpenAlex
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