Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis
DSAD shows greater lipid peroxidation than AD consistent with greater MBs and iron load. DSAD also shares similar and more pronounced features of AD such as decreased protein levels of critical GSH producing enzyme GCLM and other protective mechanisms against lipid peroxidation. The extensive increase of iron and lipid peroxidation suggests their linkage to APP gene dosage. The impairment of these key mechanisms asserts ferroptosis as a key feature during AD.
Authors
- Henry Jay Forman (ORCID: https://orcid.org/0000-0001-5838-2791)
- Marc Vermulst (ORCID: https://orcid.org/0000-0003-4909-5496)
- José A. Godoy-Lugo (ORCID: https://orcid.org/0000-0003-4671-3201)
- Caleb E. Finch (ORCID: https://orcid.org/0000-0002-7617-3958)
- Max A. Thorwald
- Elizabeth Head
Institutions
- University of Southern California (US)
- University of California, Merced (US)
- University of California, Irvine (US)
- University of California System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105930
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07