Association between DPP‐4 inhibitor use and changes in dementia‐related plasma biomarkers in older adults with type 2 diabetes: post‐hoc analyses of J‐MINT
Our findings align with preclinical evidence that DPP-4 inhibitors may attenuate Alzheimer's disease pathology progression in individuals with type 2 diabetes. Further studies with larger sample sizes are needed to confirm these results.
Authors
- Elizabeth M. Rhea (ORCID: https://orcid.org/0000-0001-8118-120X)
- Taiki Sugimoto
- Takashi Sakurai (ORCID: https://orcid.org/0000-0001-9515-6574)
- Hisashi Noma (ORCID: https://orcid.org/0000-0002-2520-9949)
- Hidenori Arai
- Kazuaki Uchida
- Yujiro Kuroda
- Kosuke Fujita
- Yoko Yokoyama
- Ayaka Onoyama
- Takuya Omura
- Akinori Nakamura
- Paul K Crane
- J‐MINT study group
Institutions
- University of Washington (US)
- VA Puget Sound Health Care System (US)
- The Institute of Statistical Mathematics (JP)
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101474
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00