Astrocyte reactivity and neurodegeneration biomarkers in critical care patients and strategies for intervention
Critical care diseases influence astrocyte reactivity and neurodegeneration, suggesting that severe systemic diseases may be associated with neuropathological processes. Besides, astrocyte reactivity was associated with mortality prediction scores. These results emphasize the need for further research into GFAP and NfL as biomarkers to better understand and manage neurodegeneration in critical care settings.
Authors
- Fabiano Márcio Nagel (ORCID: https://orcid.org/0000-0002-8055-864X)
- Christian Limberger (ORCID: https://orcid.org/0000-0002-5160-3886)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Débora Guerini de Souza (ORCID: https://orcid.org/0000-0003-2982-4989)
- João Pedro Uglione da Ros (ORCID: https://orcid.org/0009-0000-1570-0366)
- Francieli Rohden (ORCID: https://orcid.org/0000-0002-9232-7371)
- Pedro Rodrigues Vidor (ORCID: https://orcid.org/0000-0001-9208-7323)
- Diogo O. Souza
- Monica Ochoa Nagel
- Lara Angi Souza
- Wyllians Vendramini Borelli
- Jaderson Costa da Costa
- Isabela Scur Carrard
- Eduardo R. Zimmer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Instituto do Cérebro (BR)
- Hospital Moinhos de Vento (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Universidade Luterana do Brasil (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_103480
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00