Fibrillar tau promotes endothelial dysfunction through RAGE signaling and AGEs production

Our results suggest that fibrillar tau induces activation of RAGE signaling pathways, ultimately leading to loss of EC barrier function coupled with proinflammatory EC activation. Further, tau-mediated AGE production may serve as an intermediate in this process, sustaining RAGE activation and metabolic alterations. Overall, our results provide insight into the mechanisms of tau-mediated EC dysfunction.