Changes in Gut Microbiota and Short‐Chain Fatty Acids in Different Stages of Alzheimer's Disease
These findings suggest that changes in gut bacteria and their metabolites vary at different stages of AD. Key results show that certain bacteria, such as Firmicutes, Bacteroidetes, and Proteobacteria, are linked to SCFAs, especially butyric acid, which plays a role in gut and brain health. This suggests that modifying gut bacteria could help regulate SCFA levels and potentially slow the progression of AD. However, more research is needed to fully understand this connection.
Authors
- Karen P. Scott (ORCID: https://orcid.org/0000-0002-4608-0013)
- Sithara Udeshini Dissanayaka
- W. M. A. D. Binosha Fernando
- Thilini Jayasingh
- Stephanie R Rainey‐Smith
- Hamid R Sohrabi
- Ralph N Martins
Institutions
- Edith Cowan University (AU)
- The University of Sydney (AU)
- Murdoch University (AU)
- Australian Alzheimer’s Research Foundation (AU)
- Ecologie microbienne (FR)
- Dementia Australia (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105512
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00