Changes in Gut Microbiota and Short‐Chain Fatty Acids in Different Stages of Alzheimer's Disease

These findings suggest that changes in gut bacteria and their metabolites vary at different stages of AD. Key results show that certain bacteria, such as Firmicutes, Bacteroidetes, and Proteobacteria, are linked to SCFAs, especially butyric acid, which plays a role in gut and brain health. This suggests that modifying gut bacteria could help regulate SCFA levels and potentially slow the progression of AD. However, more research is needed to fully understand this connection.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_105512
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Changes in Gut Microbiota and Short‐Chain Fatty Acids in Different Stages of Alzheimer's Disease

Karen P. Scott, Sithara Udeshini Dissanayaka, W. M. A. D. Binosha Fernando, Thilini Jayasingh et al.
Alzheimer s & Dementia
Gut microbiota and health
article

Changes in Gut Microbiota and Short‐Chain Fatty Acids in Different Stages of Alzheimer's Disease

Karen P. Scott, Sithara Udeshini Dissanayaka, W. M. A. D. Binosha Fernando, Thilini Jayasingh, Stephanie R Rainey‐Smith, Hamid R Sohrabi, Ralph N Martins
article en

Abstract

These findings suggest that changes in gut bacteria and their metabolites vary at different stages of AD. Key results show that certain bacteria, such as Firmicutes, Bacteroidetes, and Proteobacteria, are linked to SCFAs, especially butyric acid, which plays a role in gut and brain health. This suggests that modifying gut bacteria could help regulate SCFA levels and potentially slow the progression of AD. However, more research is needed to fully understand this connection.

Alzheimer s & DementiaVol. 21(S1)
Edith Cowan University (AU), The University of Sydney (AU), Murdoch University (AU), Australian Alzheimer’s Research Foundation (AU), Ecologie microbienne (FR), Dementia Australia (AU), Macquarie University (AU)
Openalex Percentile: Top 36%
Gut microbiota and health
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Changes in Gut Microbiota and Short‐Chain Fatty Acids in Different Stages of Alzheimer's Disease — Karen P. Scott, Sithara Udeshini Dissanayaka, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS