Volumetric alterations of subcortical grey matter as diagnostic indicators for Dementia

Our investigation into the GMVs of subcortical areas revealed that in Dementia patients both the atrophy and the inflammation characterize pathological alterations, uncovering the consequences of sustained neuroinflammation on brain tissue and the resulting pathogenesis of Dementia. Besides, based on the ROC curve the GMVs of subcortical areas serve as a reliable biomarker for early detection and diagnosis of Dementia in clinical settings, facilitating timely interventions.