Harnessing Individual Omics Signatures for Precision Medicine in Alzheimer's Disease

Our findings underscore the molecular heterogeneity of AD, revealing individual and sex-dependent functional dysregulation better captured through single-subject analyses than cohort-based approaches. Clustering identified biologically distinct subgroups, some correlating with cognitive measures, providing potential biomarkers for refined disease stratification. These insights offer a framework for precision medicine in AD, guiding targeted therapeutic strategies based on individualized omics molecular signatures.