Utility of Plasma pTau217 and NF‐L in Predicting β‐Amyloid Status: Findings from a Multicenter Study in Catalonia

Plasma pTau217 showed high AD diagnostic accuracy, and may reduce the need for other procedures like CSF/PET. The use of two diagnostic thresholds appears optimal, with 26% of subjects in intermediate ranges, potentially indicating early AD changes. NF-L were elevated in neurodegeneration but showed limited clinical utility in our study. This study supports the use of pTau217 in clinical practice, promoting diagnostic uniformity across Catalonia.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_101518
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Utility of Plasma pTau217 and NF‐L in Predicting β‐Amyloid Status: Findings from a Multicenter Study in Catalonia

Susana Fernández González, Núria Guillén, T Casadevall, Lorena Bajo Peñas et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Utility of Plasma pTau217 and NF‐L in Predicting β‐Amyloid Status: Findings from a Multicenter Study in Catalonia

Susana Fernández González, Núria Guillén, T Casadevall, Lorena Bajo Peñas, J Sarto, Josep M. Augé, Fernando José Espada Olivan, Isabel Gómez‐Ruiz, Raquel R. Cuevas, Claustre Pont Sunyer, A. Lladó, Guadalupe Fernández‐Villullas, Miquel Massons, Roger Puey, Neus Falgàs Martínez, Joan Bello López, Teresa Romero, Marta Balagué Marmaña, Mircea Balasa, Sergi Borrego‐Écija, Eva Bonjoch Jaques, Magdalena Castellví, Laura Iglesias, Anna Colmenero, Maira Teresa Osuna Pulido, Anna Carnes, Anuncia Boltes Alandí, Sara de la Fuente Olanda, Lorena Grau Guinea, Marta Culell Juncà, Sara Carrillo, Iolanda Riba Llena, Anna Antonell, Gerard Piñol‐Ripoll, Adrià Tort‐Merino, Raquel Sánchez‐Valle
article en

Abstract

Plasma pTau217 showed high AD diagnostic accuracy, and may reduce the need for other procedures like CSF/PET. The use of two diagnostic thresholds appears optimal, with 26% of subjects in intermediate ranges, potentially indicating early AD changes. NF-L were elevated in neurodegeneration but showed limited clinical utility in our study. This study supports the use of pTau217 in clinical practice, promoting diagnostic uniformity across Catalonia.

Alzheimer s & DementiaVol. 21(S2)
Hospital Universitari de Santa Maria (ES), Hospital General de Granollers (ES), Hospital Clínic de Barcelona (ES), Fundació Salut i Envelliment UAB (ES), Hospital de Sant Joan Despí Moisès Broggi (ES), Instituto de Investigación Biomédica de Lleida (ES), Hospital Sant Jaume de Calella (ES), Hospital Universitari de Vic (ES), Fundació Clínic per a la Recerca Biomèdica (ES)
Openalex Percentile: Top 34%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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