Genome‐Wide Analyses for cognitive performances in Multi‐Ethnic Cohorts identifies novel rare locus <i>PCAT5</i>

This study provides strong evidence for the association of rare variants within PCAT5 and cognitive performances across different populations. Importantly, a rare variant in PCAT5 was previously reported in a large meta-analysis for ADRD of 65,602 Non-Hispanic Whites (Naj, 2021). These findings suggest that PCAT5 may play a role in ADRD pathology independently of APOE, warranting further biological investigations to understand the mechanisms underlining this gene's role.