Age‐Related Degeneration of the Motor Cortex and White Matter Tracts: Insights from Structural and Perfusion MRI

Aging is characterized by reductions in MC volume, CBF, and white matter integrity, alongside increases in T1/T2 ratio, curvature, and ATT. The MC-striatum tract demonstrates a link to cognitive decline in aging, with its degeneration associated with structural and functional impairments in the MC. These findings provide insights into early alterations potentially linked to age-related dementia and aid in their differential diagnosis.