p75 neurotrophin receptor: a prototype therapeutic target modulating fundamental mechanisms of degeneration and glial function in Alzheimer’s and related dementias

These findings support the hypothesis that modulation of p75NTR signaling, a key mechanism and hub upstream from a broad network of AD/ADRD degenerative signaling networks, leads to a reduction of synaptic and glial pathology. The transcriptomic findings indicate some degree of overlap between the mouse findings and human AD degenerative mechanisms. This overlap and these preclinical findings are consistent with biomarker and proteomic findings observed in a recent phase 2a clinical trial of LM11A-31 with mild-moderate AD participants.