Real-Life Long-Term Weight Trends After Switching to INSTI-Based Therapy in People Living with HIV: A 12-Year Retrospective Cohort Study.
Switching from PI- to INSTI-based cART in virologically suppressed PLWH is associated with modest but sustained increases in body weight and BMI over time, without evident deterioration in metabolic health. These results support the favourable safety profile of INSTIbased regimens while underscoring the need for routine anthropometric monitoring and preventive lifestyle interventions during long-term therapy.
Authors
- Luigi PETRAMALA
- Gioacchino Galardo (ORCID: https://orcid.org/0000-0001-5941-9947)
- Myriam Maiorano
- Giancarlo Ceccarelli (ORCID: https://orcid.org/0000-0001-5921-3180)
- Luca Bortolani (ORCID: https://orcid.org/0009-0001-3987-2303)
- Paolo Vassalini (ORCID: https://orcid.org/0000-0002-6336-0455)
- Alessandro Lazzaro (ORCID: https://orcid.org/0000-0002-6297-9387)
- Marco Ridolfi
- R Donà
- Edoardo Bogliolo
- F. Romano (ORCID: https://orcid.org/0000-0002-9491-748X)
- Mattia Albanese
- Daniele Giangiulio
- Gabriella d'Ettorre
- Giulia d'Amati
- Francesco Branda
- Irene De Angelis
Institutions
- Università Campus Bio-Medico (IT)
- Policlinico Umberto I (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- PubMed
- Published
- 2025-12-01
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00