In vitro activity of Cefepime/Enmetazobactam and Cefepime/Zidebactam against OXA-48-producing Klebsiella pneumoniae clinical strains.

In this study, we evaluated the in vitro antibacterial activity of cefepime/enmetazobactam and cefepime/zidebactam against well-characterized OXA-48-like producing Klebsiella pneumoniae clinical strains. Genomic analysis revealed that all strains carried class D carbapenemase including blaOXA-48 and blaOXA-181 as well as different ESBL genes. Our results demonstrated that both enmetazobactam and zidebactam significantly enhanced the bactericidal activity of cefepime in vitro. Based on these findings, we suggest that these combinations could be considered a valuable therapeutic approach for treatment of infections caused by OXA-48-producing K. pneumoniae.