The Role of Therapeutic Plasma Exchange in Treatment of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy.

Key Ideas Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a recently identified inflammatory central nervous system (CNS) disorder marked by GFAP-IgG autoantibodies. Therapeutic plasma exchange (TPE) removes pathogenic autoantibodies, cytokines, and immune complexes, thereby targeting the disease's core immunopathology. TPE is a rational and potentially lifesaving therapy in autoimmune GFAP astrocytopathy, especially in refractory or life-threatening cases.