Dissecting the role of SEPHS1 in shaping an immunosuppressive microenvironment to promote tumor progression
SEPHS1 promotes immune evasion in melanoma by suppressing chemokines and limiting CD8⁺ T cell infiltration. Targeting SEPHS1 restores immune activity and potentiates immune checkpoint blockade, suggesting a novel immunometabolic strategy to enhance cancer immunotherapy.
Authors
- Yiqi Tan
- Y D Cheng
- Yulong Huang (ORCID: https://orcid.org/0000-0002-4261-775X)
- Yujie Cui (ORCID: https://orcid.org/0000-0002-8254-6474)
- Ke Cao
- Yunqing Liu
- Zhijie Gao
- Wenxi Ji
- Xiaotian Yuan
- Guanjun Chen
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1007/s00262-025-04253-3
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00