Dissociation of hypometabolism and atrophy and implications on biomarker use in Alzheimer's disease
Atrophy and hypometabolism show distinct patterns of alteration in AD, aligning with different behavioral changes. This dissociation suggests that atrophy and hypometabolism may have distinct underlying neuropathologies. We advocate for the inclusion of atrophy and hypometabolism as separate biomarker categories in AD biomarker profiling.
Authors
- Annie Dang (ORCID: https://orcid.org/0000-0003-2968-5990)
- Peter T Fox
- Di Wang
- Mohamad Habes
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- The University of Texas at San Antonio (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_097046
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00