polyGR produced by CASP8 GGGAGA repeat expansion increases phosphorylation of Tau
In summary, our results demonstrate polyGR aggregates can contribute to tau pathology and activation of caspase-8 related pathways in AD. Additionally, increased oxidative stress favors the accumulation of polyGR-containing proteins and related pathways, leading to increased AD pathological hallmarks.
Authors
- Lien Nguyen (ORCID: https://orcid.org/0000-0001-5237-2576)
- Logan Bell (ORCID: https://orcid.org/0009-0005-9403-888X)
- Huong T. Phuong
- Rodrigo Francisco Tomas
- Cemal Akamese
Institutions
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102925
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00