Sialylated Clusterin Binds CD33 to Regulate Microglial Functions in Alzheimer's Disease
This study identifies CLU as a specific CD33 ligand and highlights its role in modulating microglial functions via CD33 ITIM signaling. Sialylated CLU inhibits Aβ uptake and amyloid plaque clearance, suggesting a potential mechanism underlying microglial dysfunction in AD. These findings underscore the therapeutic potential of targeting the CD33-CLU axis to restore microglial homeostasis and enhance amyloid clearance in AD.
Authors
- Jean Sévalle
- Elizabeth M. Bradshaw (ORCID: https://orcid.org/0000-0002-6766-4325)
- Kanayo Satoh (ORCID: https://orcid.org/0009-0000-4520-2560)
- Christopher Böhm
- P. E. Fraser
- Peter St George‐Hyslop (ORCID: https://orcid.org/0000-0003-0796-7209)
- Masahiro Enomoto (ORCID: https://orcid.org/0000-0002-9411-2999)
- Roger B. Dodd (ORCID: https://orcid.org/0000-0003-4268-1863)
- Deniz Ghaffari
- Mamunur Rashid (ORCID: https://orcid.org/0000-0001-6768-1814)
- M. G. Wilson
- F.-C. Chen
- Beatrice Acheson
- Seema Qamar (ORCID: https://orcid.org/0009-0002-6011-5785)
- Ye Zhou
- Yalun Zhang
- Jennifer K Griffin
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- University of Wollongong (AU)
- University of Cambridge (GB)
- Bridge University (SS)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100929
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00