Associations between regional amyloid PET and genome‐wide polygenic risk scores in the predementia AMYPAD consortium
PRS prediction was strongest in the frontal cortex, with PRS<sub>amyloid</sub> and PRS<sub>Kunkle</sub> performing similarly at stringent SNP inclusion thresholds. PRS<sub>amyloid</sub> performed slightly better despite different biological enrichment. These findings, stronger in men, enhance our understanding of the genetic basis of amyloid pathology and support the potential of genetic profiling for identifying at-risk individuals, with potential sex differences.
Authors
- Emma S. Luckett (ORCID: https://orcid.org/0000-0003-1777-4742)
- Lanius
- Yasmina Abakkouy (ORCID: https://orcid.org/0000-0002-6601-4048)
- Natalia Vilor‐Tejedor
- Rik Vandenberghe
- Lyduine E. Collij
Institutions
- Radboud University Nijmegen (NL)
- Queen Mary University of London (GB)
- Lund University (SE)
- Radboud University Medical Center (NL)
- Pasqual Maragall Foundation (ES)
- Amsterdam Neuroscience (NL)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Centre for Genomic Regulation (ES)
- Amsterdam University Medical Centers (NL)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104356
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00