Fulacimstat Reduces Angiotensin II in Kidney Allografts in a Cross-Sectional Exploratory Study
Chymase is the key enzyme for Ang II production in aged graft vintage (> 2 years). Selective inhibition of tissue-specific chymase with fulacimstat (BAY 1142524) inhibits Ang II formation in human kidney allografts, indicating potential therapeutic effects.
Authors
- Hanna Tinel (ORCID: https://orcid.org/0000-0002-5518-384X)
- M. D. Saemann
- Tarik Shoumariyeh (ORCID: https://orcid.org/0000-0001-9155-1112)
- Klaus G. Schmetterer (ORCID: https://orcid.org/0000-0001-9328-4871)
- J Kovarík (ORCID: https://orcid.org/0000-0002-0206-082X)
- Christopher C. Kaltenecker
- Oliver Domenig
- Marko Poglitsch
- Chantal Kopecky
Institutions
- Sigmund Freud Privatuniversität Wien (AT)
- UNSW Sydney (AU)
- Australian Centre for Advanced Computing and Communications (Australia) (AU)
- Bayer (Germany) (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1016/j.ekir.2025.103745
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00