Senolytic treatment with Quercetin and Dasatinib mitigates decline in cardiac function and links heart remodeling to cognitive performance in adult Dahl Salt‐Sensitive Female Rats
Chronic senolytic treatments with QRC or QRC+DAS protected heart function and reduced anxiety-like behavior but did not affect EVA in adult DSS females. The correlation between cardiac remodeling and attention test performance highlights a potential heart-brain interaction. Supported by NIA/NIH/IRP.
Authors
- Valentina Zernetkina
- Edward G. Lakatta (ORCID: https://orcid.org/0000-0002-4772-0035)
- Christopher H. Morrell (ORCID: https://orcid.org/0000-0001-5080-7142)
- Ross A. McDevitt
- Mackenzie J Barnett
- Olga V Fedorova
- Wen Wei
- Carla Rocha Dos Santos
Institutions
- National Institutes of Health (US)
- National Institute on Aging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104317
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00