Associations between neurodegenerative and acute injury biomarkers and post‐stroke cognitive impairment – the Nor‐COAST study
Concentrations of plasma BD-tau, NfL, GFAP, and t-tau were increased in the acute phase of stroke, but no significant change was seen for Aβ<sub>42</sub>. BD-tau, t-tau and GFAP concentrations decreased to stable levels within 3 months of event, NfL stabilized within 18 months, whereas p-tau181 showed an increase. Higher concentrations of BD-tau, NfL, and p-tau<sub>181</sub> were associated with worse cognitive outcome up to 36 months post-stroke. These results indicate that stroke trigger a continuing neurodegenerative process, as demonstrated by gradually increasing concentrations of p-tau<sub>181</sub> leading to PSCI.
Authors
- Heidi Vihovde Sandvig (ORCID: https://orcid.org/0000-0002-0591-8377)
- Kaj Blennow
- Nicholas W. Ashton (ORCID: https://orcid.org/0000-0002-9708-6319)
- Guglielmo Di Molfetta
- Henrik Zetterberg
- Stina Vihovde Aam
- Ingvild Vihovde Saltvedt
- Anne‐Brita Knapskog
Institutions
- Oslo University Hospital (NO)
- King's College London (GB)
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101515
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00