Exploring the therapeutic potential of metformin on cognitive function, amyloid pathology, and microglial homeostasis in Alzheimer's disease models
Our results indicate that metformin may have a therapeutic effect in AD models restoring cognitive performance. This effect appears to be due to a microglial gain of function by rehabilitating the autophagic flux blocked by amyloid peptides. Metformin may also contribute to the reduction of amyloid pathology and improvement of hippocampal neurogenesis.
Authors
- Soledad Porte Alcón (ORCID: https://orcid.org/0000-0002-0381-0880)
- Melisa Bentivegna
- Jessica Presa (ORCID: https://orcid.org/0000-0002-7508-0055)
- Natalí B. Rasetto (ORCID: https://orcid.org/0000-0002-8614-3824)
- Juan Beauquis (ORCID: https://orcid.org/0000-0003-1404-5632)
- Carlos Pomilio
- Nicolás Gabriel González Pérez
- Luciano Arcucci
- Flavia Saravia
- Melina Paula Bellotto
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Buenos Aires (AR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102986
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00