Ghrelin mitigates partial body irradiation-induced gastrointestinal acute radiation syndrome by promoting intestinal stem cell regeneration
These findings indicate that ghrelin mitigates radiation-induced intestinal injury by promoting the expansion of Clu<sup>+</sup> revival stem cells and the recovery of intestinal stem cells. This study highlights the therapeutic potential and identifies the mechanism of action of ghrelin as a medical countermeasure against GI-ARS.
Authors
- Satoshi Yamaga
- Atsushi Murao (ORCID: https://orcid.org/0000-0001-9801-3923)
- Max Brenner (ORCID: https://orcid.org/0000-0002-8010-148X)
- Dmitriy Lapin
- Yongchan Lee
- Wayne Chaung
- Ping Wang
Institutions
- Feinstein Institute for Medical Research (US)
- Hofstra University (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s10020-025-01399-9
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health