LOAD3: A new preclinical mouse model that incorporates humanized <i>APOE4</i> , Aβ and <i>MAPT</i>
LOAD3 (LOAD3*E4) and LOAD3*E3 are platform strains to enhance preclinical studies for AD. MODEL-AD and TOX-AD are using LOAD3 strains to evaluate additional genetic and environmental risk factors for ADRD.
Authors
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Dylan Garceau
- Catrina Spruce
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
- Alison Burman
- Gregory W Carter
Institutions
- Tufts University (US)
- Jackson Laboratory (US)
- University of Maine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104914
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00