Fibroblasts from Niemann Pick type C patients are more prone to autophagy induction than fibroblasts from healthy individuals under starvation conditions and Chloroquine treatment

NPC fibroblast cells were more prone to induction of the first phases of autophagy when treated with Chloroquine under starvation conditions compared to fibroblasts from healthy individuals. This result was confirmed by Cyto-ID autophagy assay and LC3-II increase expression. These cells derived from NPC patients constitute an optimal model to study this neurodegenerative disease in vitro.