Neuronal transcriptional changes associated with incipient Alzheimer's disease neuropathology in entorhinal cortex

We highlight here the complex multicellular landscape of EC during the silent phase of AD, when the disease is still largely confined to this region. While the precise mechanisms of pathway dysregulation and the communication between the different highlighted cell types, remain to be discovered, our study paves the way for detailed characterization of the mechanisms governing NFT formation and opens long-needed novel therapeutic avenues.