Maternal DNA methylation signatures of gestational diabetes across all stages of pregnancy
We conclude that DNA methylation changes during pregnancy might not fully explain GDM pathogenesis but can reflect population-specific environmental and behavioral factors before and during pregnancy. Some of these discovered CpG sites might regulate previously reported genes linked to GDM and diabetes, highlighting shared and distinct epigenetic mechanisms across populations.
Authors
- Odette Chagoury (ORCID: https://orcid.org/0000-0002-1723-9056)
- Nergiz Gürbüz Çolak (ORCID: https://orcid.org/0000-0003-1100-910X)
- Eleni Fthenou (ORCID: https://orcid.org/0000-0002-1178-6841)
- Nady El Hajj (ORCID: https://orcid.org/0000-0003-3420-8531)
- Yosra Bejaoui (ORCID: https://orcid.org/0000-0003-1617-5756)
- Abeer Qannan
- Luma Srour (ORCID: https://orcid.org/0000-0002-5585-4455)
- Noha A. Yousri (ORCID: https://orcid.org/0000-0003-1918-0331)
- Jayakumar Jerobin
- Manar Dweik
- Mohammed Bashir
- Thomas Farrell
- Aswathy Sankar
Institutions
- Hamad bin Khalifa University (QA)
- Weill Cornell Medical College in Qatar (QA)
- Hamad Medical Corporation (QA)
- Qatar University (QA)
- Alexandria University (EG)
- Qatar Foundation (QA)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s12967-025-07237-0
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qatar Foundation
- Fonds National de la Recherche Luxembourg
- Qatar National Research Fund