Use of untargeted metabolomics for the study of pediatric neurometabolic disorders: A review

Untargeted metabolomics is an unbiased and powerful tool in the field of NMD. Further technical improvements, larger databases and reduced analytical costs, combined with worldwide collaboration and standardization regarding preanalytical and analytical aspects, is expected to make this a cost-effective supplement to targeted analyses in the field of NMD. Are we finally entering the metabolomics era?

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Publication Details

Journal
Molecular Genetics and Metabolism
Published
2025-12-24
DOI
https://doi.org/10.1016/j.ymgme.2025.109711
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
article
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article

Use of untargeted metabolomics for the study of pediatric neurometabolic disorders: A review

Aruna Gowdra, Helge Rootwelt, Cathrin Lytomt Salvador, Alfonso de Oyarzábal Sanz et al.
Molecular Genetics and Metabolism
Metabolomics and Mass Spectrometry Studies
article

Use of untargeted metabolomics for the study of pediatric neurometabolic disorders: A review

Aruna Gowdra, Helge Rootwelt, Cathrin Lytomt Salvador, Alfonso de Oyarzábal Sanz, Paula Juliana Rodríguez-Soler, Cristian Irela Aranda
article en

Abstract

Untargeted metabolomics is an unbiased and powerful tool in the field of NMD. Further technical improvements, larger databases and reduced analytical costs, combined with worldwide collaboration and standardization regarding preanalytical and analytical aspects, is expected to make this a cost-effective supplement to targeted analyses in the field of NMD. Are we finally entering the metabolomics era?

Molecular Genetics and MetabolismVol. 147(1)
Oslo University Hospital (NO), Hospital Sant Joan de Déu Barcelona (ES), Universitat Abat Oliba CEU (ES), Universidad Regional Miguel Hidalgo (MX), Indira Gandhi Institute of Child Health (IN), Hospital Universitario Infantil San José (CO)
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Openalex Percentile: Top 36%
Metabolomics and Mass Spectrometry Studies
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