Prognostic and Disease Tracking Capability of Light Reflex Pupillometry and Actigraphy in Early Alzheimer's Disease
Our results indicate that dynamic pupillary changes were associated with a higher risk of progression, possibly reflecting changes in arousal states. qLRP also correlated with disease progression along the disease continuum. The same pattern was found for several actigraphic parameters, indicating that decreases in nighttime activity were indicative of disease progression. This study demonstrates the usefulness of two promising digital biomarkers for AD easing prognostication and disease tracking.
Authors
- Ian G. Law (ORCID: https://orcid.org/0000-0001-9644-7496)
- Ulrich Lindberg (ORCID: https://orcid.org/0000-0002-0004-6354)
- Frederikke Kragh Clemmensen (ORCID: https://orcid.org/0000-0001-7374-2919)
- Otto Mølby Henriksen (ORCID: https://orcid.org/0000-0002-1011-6934)
- Poul Jennum (ORCID: https://orcid.org/0000-0001-6986-5254)
- Mathias Holsey Gramkow (ORCID: https://orcid.org/0000-0002-3827-6489)
- Steen G. Hasselbalch
- Kristian Steen Frederiksen
- Gunhild Waldemar
- Andreas Brink‐Kjær
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_097029
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00