Molecular Subtyping of Alzheimer's Disease with Mixed Pathology from a Single Nucleus/Cell Transcriptomics Atlas
Constructing an AD atlas at a single-cell/nucleus resolution enabled us to identify changes specific to AD compared to MCI and Control samples. Furthermore, we defined novel AD subtypes using a simple autoencoder-based classification approach. These findings provide a foundation for subtype-specific research and therapeutic development in AD.
Authors
- Zechuan Shi (ORCID: https://orcid.org/0000-0002-2844-5816)
- Samuel Morabito (ORCID: https://orcid.org/0000-0002-7768-4856)
- Negin Rahimzadeh (ORCID: https://orcid.org/0000-0002-7797-620X)
- Vivek Swarup
Institutions
- University of California, Los Angeles (US)
- University of California, Irvine (US)
- UC Irvine Health (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103590
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00