Assessing the relationship of systemic proinflammatory biomarkers in the Alzheimer's disease cognitive spectrum using ER176 neuroinflammation PET
Although significant relationships between systemic inflammation, brain amyloid and neuroinflammation were limited, the data show an overarching trend bias in broad brain regions, suggesting that further analyses are needed, possibly with larger sample sizes, to assess the relationship of regional neuroinflammation and amyloid to systemic inflammation. Future analyses could also regress out factors like sex, age, and genotype to further proinflammatory cytokine research.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Jeyeon Lee (ORCID: https://orcid.org/0000-0002-6168-8385)
- Jonathan Graff‐Radford
- Hugo Botha
- Seokbeen Lim (ORCID: https://orcid.org/0000-0002-4142-3478)
- Emily S. Lundt (ORCID: https://orcid.org/0000-0002-4754-8642)
- R. C. Petersen
- Paul H Min
- David S. Knopman
- Kejal Kantarci
- Mahathi Kandimalla
- Clifford R. Jack
- David N Jacobson
- Prashanthi Vemuri
- David T. Jones
Institutions
- Mayo Clinic in Arizona (US)
- Hanyang University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106903
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00