AAV‐Tau injection in the substantia nigra as a rapid and robust mouse model of tauopathies with Parkinsonian features

The early development of motor deficits and regional brain atrophy observed in AAV-Tau-injected mice makes this translational model a valuable and reliable tool for preclinical efficacy studies aimed at accelerating the development of disease-modifying therapeutic interventions for tauopathies with Parkinsonian features, such as Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD).

Authors

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_102244
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

AAV‐Tau injection in the substantia nigra as a rapid and robust mouse model of tauopathies with Parkinsonian features

Anastasia Noël, Élodie Brison, Barry J Bedell
Alzheimer s & Dementia
Parkinson's Disease Mechanisms and Treatments
article

AAV‐Tau injection in the substantia nigra as a rapid and robust mouse model of tauopathies with Parkinsonian features

Anastasia Noël, Élodie Brison, Barry J Bedell
article en

Abstract

The early development of motor deficits and regional brain atrophy observed in AAV-Tau-injected mice makes this translational model a valuable and reliable tool for preclinical efficacy studies aimed at accelerating the development of disease-modifying therapeutic interventions for tauopathies with Parkinsonian features, such as Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD).

Alzheimer s & DementiaVol. 21(S1)
Openalex Percentile: Top 31%
Parkinson's Disease Mechanisms and Treatments
DOIOpen Access PDFOpenAlex
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AAV‐Tau injection in the substantia nigra as a rapid and robust mouse model of tauopathies with Parkinsonian features — Anastasia Noël, Élodie Brison, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS