MistGo® Compared to Conventional Eye Drops: A Patient-Reported Evaluation of Comfort and User-Friendliness in Glaucoma Treatment

<b>Background/Objectives</b>: Poor adherence remains a key challenge in glaucoma management, often due to difficulties with accurate self-administration and discomfort associated with conventional eye drop bottles. MistGo^® is a novel dispensing device that delivers precise micro-doses of medication as a fine mist, allowing dosing with a neutral head position. With its ergonomic design, eye rest, and dose release button, MistGo^® aims to improve comfort and ease of use. This study compared the user-friendliness, comfort, and administration confidence of MistGo^® versus conventional eye drop dispensers in patients using topical ocular hypotensive medications. <b>Methods</b>: Twenty-two patients with glaucoma or ocular hypertension who had used conventional eye drop dispensers for ≥3 months were enrolled. Participants used the MistGo^® device for 14 days and subsequently rated comfort, user-friendliness, and administration confidence on 0-10 scales for both their conventional dispensers and the MistGo^® device. <b>Results</b>: MistGo^® was rated significantly higher than conventional eye drop dispensers in terms of comfort (<i>p</i> < 0.0001), caused less discomfort from excess fluid (<i>p</i> < 0.001), and was perceived as more user-friendly (<i>p</i> < 0.001). There was no significant difference in the perceived accuracy of administration (<i>p</i> = 0.5); however, participants reported a significantly lower likelihood of medication being applied outside the eye when using MistGo^® (<i>p</i> < 0.001). Overall, 20 out of 22 patients preferred MistGo^®. <b>Conclusions</b>: Patients with glaucoma or ocular hypertension preferred MistGo^® over conventional eye drop dispensers as they found it more comfortable and user-friendly. These findings suggest that MistGo^® has the potential to reduce barriers to adherence in glaucoma care. Further studies are warranted to evaluate its long-term efficacy and broader applicability.