Cell‐Type Specific Contributions to Metabolic Connectivity in an Alzheimer's Disease Mouse Model
These findings suggest that microglia are the primary drivers of the increased forebrain-hindbrain metabolic connectivity observed in the AD mouse model. Further RNA expression analyses could provide valuable insights into the molecular mechanisms underlying microglial metabolic coupling in neurodegeneration.
Authors
- Stephan Wagner (ORCID: https://orcid.org/0000-0002-3184-2599)
- Artem Zatcepin (ORCID: https://orcid.org/0000-0002-0224-088X)
- Sabina Tahirović (ORCID: https://orcid.org/0000-0003-4403-9559)
- Johannes Gnörich (ORCID: https://orcid.org/0000-0003-1554-7765)
- Laura M. Bartos (ORCID: https://orcid.org/0009-0007-6158-319X)
- Valerio Zenatti
- Danilo Prtvar (ORCID: https://orcid.org/0009-0004-8251-1441)
- Manvir Lalia
- Justus Flinn Thevis
- Selina Hummel
- Matthias Brendel
Institutions
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105605
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00