Decoding the effects of Bexarotene treatment on brain of AD‐like model mice: single‐cell transcriptomics and chromatin accessibility analysis

Bexarotene upregulates RXR-controlled gene networks in major brain cell types, including microglia and endothelial cells. The combined analysis of single-cell transcriptomics, ATAC-seq, and ChIP-seq provides new insights into how RXR activation may restore brain homeostasis by regulating neuroinflammation, amyloid deposition, and neuronal damage. This research highlights the complexity of TF signaling pathways and their potential for therapeutic use in AD.